Pharmacology Research & Evaluation

SGene offers preclinical CRO services, including drug efficacy evaluation, pharmacological and pharmacokinetic (PK) analysis, and drug safety evaluation (Non-GLP).

Our services are of better quality, established scientific experience, economic stability and better logistics. Our technical team are fully experienced in helping clients to accelerate their preclinical drug development by providing professional CRO services.

  • Atherosclerosis (ApoE) canine model

    Myocardial infarction canine model

    Myocardial infarction porcine model

    Nasopharyngeal carcinoma rabbit model

    Cardiovascular System
  • Liposome-induced liver cancer canine model

    Specific delivery colorectal cancer canine model

    Popliteal lymph node metastasis rabbit model

    Oncology
  • ASD canine model

    Alzheimer's disease canine model

    Schizophrenia cainie model

    CNS
  • Infertility canine model

    Endometriosis rabbit model

    Cystectomy porcine model

    Urology
  • COPD porcine model

    Pulmonary embolism rabbit model

    Pulmonary embolism canine model

    Pulmonary hypertension porcine model

    Respiratory system
  • Articular cartilage defect rabbit model

    Articular cartilage defect sheep model

    Growing rods implanted in mini-pigs

    Bone defect sheep model


    Skeletal system
  • Glucose tolerance canine model

    Gck canine model
    Metabolism
  • Rabbit scarring Model

    Rabbit acne model

    Full thickness skin removal wound healing model in mini-pigs

    Skin

Cases of Drug Efficacy Evaluation

Medical Devices Evaluation

SGene Medical Devices Evaluation Service Platform can provide customized preclinical research and evaluation services for medical devices. Based on the requirements of different experiments, appropriate animals can be selected to meet the regulatory requirements for safety and efficacy evaluations. The technical service team has extensive project experience in multiple product areas.


Our research services cover the following medical devices:

  • Vascular disease devices
  • Structural heart disease
  • Orthopedic materials
  • Ophthalmic materials (cornea)
  • Dental materials
  • Various conduits
  • Various patches
  • Various hemostatic materials
  • Various anti adhesion materials
  • Surgical indwelling materials

Cases of Drug Efficacy Evaluation

Non-GLP Toxicology

To supportdruggabilityevaluation,SGene’sexperienced safety assessment team provides non-GLP toxicology services for the nonclinical development of chemicals, biologics,and medical devices. Ourcapabilities include SPF animal facilities, fully-functional clinical testing and histopathology laboratories, and experienced toxicologists.


Our Non-GLP Preclinical Toxicology Studies

  • Single dose toxicity (acute toxicity)
  • Repeated dose toxicity (chronic toxicity)
  • NOAEL Estimation
  • Systemic toxicity
  • Local toxicity study
  • Toxicokinetic test
  • Safety pharmacology
  • Histopathology
  • Ultrasonic color Doppler imaging
  • Electrocardiogram (ECG)

Animal Species

Rodents (mice, rats, guinea pigs), rabbits, dogs, cats, pigs, non-human primates

Mice/ Rats Model Customization

SGene provides rat & mouse model customization services.


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