About SGene

SGeneis a leading large animal preclinical Contract Research Organization (CRO), providing integrated R&D services, especially in relation to large animal models across multiple species, for the global biomedical industry and academia.

Our state-of-the-art production and research bases span over 31,800 square meters in key locations such as Beijing, Shanghai and Xinyi, among others in China. These well-equipped laboratories serve as the foundation for our services ensuring high research quality and better logistics.

Our established scientific expertise ranges across various disciplines, encompassing pharmacology, pharmacokinetics, medical device evaluation, and much more.We collaborate with innovative MedTech, Biotechnology and Pharma companies and academic institutions to advance the translation of their cutting edge innovative biomedical technologies.

Our Vision, Mission & Values

Vision

A Sustainable Future of Life and Health
Mission

Empowering Pharma R&D Faster, Better and Leaner
Values

Respect for Life
Dedication to Clients
Innovation and Expertise
Integrity and Responsibility

Cloning Platform

Our cloning technology team has independently developed and created somatic cell cloning technologies for dogs, cats, and horses, and has obtained a number of original technological achievements. It is a biotechnology service enterprise with the largest number of cloned animal species in the world.

Editing Platform

Our molecular biology R&D team is proficient in knock-in, knock-out, point mutation and other gene editing processes for dogs, cats, pigs, mice, rabbits and other animals, and can develop gene-edited animal models in different species.

Benefiting from the cloning platform, the gene editing technology platform can further homogenize animal phenotypes.

Our History —— Corporate Development

YEAR

2012.11

Sinogene company established

YEAR

2015.01

R&D team built up for dog cloning

YEAR

2021.03

Sinogene Biotechnology Lab established in US

YEAR

2022.04

Sinogene CRO Beijing established

YEAR

2022.07

Sinogene Jiangsu established

YEAR

2022.11

Sinogene CRO Shanghai established

Our History —— Technology Development

2016.12

World's first gene-edited atherosclerosis canine model "Apple"

2017.05

China's first somatic cell cloned dog "Longlong" is born

2018.02

World's first gene-edited autism canine model

2018.04

China’s first batch of “test tube dogs” are born

2018.05

China’s first commercially cloned dog born

2018.06

World's first IVM-IVF dog is born

2018.12

China's first cloned police dog "Kunxun" is born

2019.06

World's first point-mutated diabetes canine model

2019.07

Chinese cloned cat "Garlic" is born

2019.08

Capital Public Security Bureau’s first batch of cloned police dogs

2019.08

World's first gene-edited amaurosis canine model

2019.10

World's first gene-edited arrhythmia canine model

2020.07

World's first gene-edited Neurodevelopmental disorders canine model

2020.08

World's first longevity gene overexpression canine model

2020.12

World's first gene-edited canine model with developmental

2021.01

World's first gene-edited schizophrenia canine model

2021.05

World's first small blood vessel gene-edited canine model

2021.06

World's first DMD gene-edited canine model

2021.09

World's first gene-edited canine model for depression

2021.12

World's first gene-edited canine model with true micro-eyeballs

2022.02

World's first gene-edited oxytocin canine model

2022.06

World's first cloned Arctic Wolf is born

2022.06

China's first registered cloned warm blooded horse

2022.09

World‘s first klotho gene-edited pig model

2022.10

Gene-edited mucopolysaccharidosis rabbit model

Core Team

Core team with strong technical and preclinical CRO service experience

Jidong Mi

Chairman and General Manager

Bachelor of Pharmacy, Hebei University, EMBA, School of Economics and Management, Tsinghua University

Years of technical management experience at Thermofisher

16 years of entrepreneurial experience, leading companyfromto annual sales of nearly 200 million yuan
Jianping Zhao

Director/Executive Deputy General Manager

Bachelor's degree in Animal Physiology and Biochemistry, School of Biology, China Agricultural University

11 years of experience in the biotechnology service industry and entrepreneurship

10 years of operation and management experience in the medical device industry
Liangxue Lai

Chief Scientist

Researcher at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, and postdoctoral fellow at the University of Missouri

Selected for the "100 Talents Program" of the Chinese Academy of Sciences, "100 Talents of Southern Guangdong", etc., and chief scientist of the National 863 and 973 projects

Bred world's first human "gene knockout" cloned pig; PI in charge of world's first gene knock-out dog functional model
Yuan Li

Director of Animal Model R&D Department

Postdoctoral fellow in Zoology at China Medical University

Expertise in creating and cultivating models of common and rare human diseases using domestic dogs, thereby providing ideal large animal models for basic research and drug efficacy evaluation of such diseases, making research results more convenient for clinical translation and application
Haiyang Hao

Animal Model researcher

PhD, School of Biology, China Agricultural University

Served as Sscientific researcher at the National Animal Gene Research Center and participated in research on breeding of improved MSTN genetically modified pigs. Extensive experience in fields of gene editing animal model vector construction, cell screening, molecular detection, cytology detection, experimental design process and experimental operation.
Xu Wei

General Manager of CRO Services

Successively founded and co-founded several technology enterprises, covering medical devices, Internet security, carbon neutral technology solutions, etc.

Over 10 years of sales, operation, and management experience in the field of biopharmaceutical devices. Formerly served as the National Sales Director of Thermofisher, China.

Qualifications & Advisors

The company's technological achievements and industry recognition have positioned it as a leader in the field, garnering acclaim from experts and institutions across China. SGene has strategically established collaborations with renowned research institutions and esteemed scientists, further solidifying its expertise and influence.

✓

Undertookhigh-precision projectof Beijing Municipal Science and Technology Commission and the Zhongguancun Management Committee: "Collaborative Innovation Platform for the Development, Transformation and Application of Gene EditedCanine Models"
✓

Established a large animal model and drug evaluation center jointly with the Beijing Institute of Brain Diseases
✓

Jointly applied for and won the key special project of "Research on the Biological Basis and Transformation of Social and Emotions" in the National Key Research and Development Program of the Ministry of Science and Technology, together with the Institute of Genetics & Kunming Institute of Zoology, Chinese Academy of Sciences, Institute of Biophysics of the Chinese Academy of Sciences, and Peking University
✓

In-depth cooperation with the Institute of Genetics of the Chinese Academy of Sciences to jointly establish "Canine Research Joint Laboratory"
✓

Serve as the drug preclinical experimental and teaching practice baseforthe School of Pharmaceutical Science and Technology, Tianjin University
✓

Serveas an off-campus practice base for graduate students of the School of Veterinary Medicine and the School of Animal Science and Technology, and established the "China Agricultural University Professor Workstation"in cooperation with China Agricultural University.

Legal and Ethical Compliance

✓

Good Quality Management Practices for Non-clinical Drug Research (National Medical Products Administration (NMPA), September 2017) (formerly State Food and Drug Administration Order No. 34)
✓

Good Laboratory Practice For Nonclinical Laboratory Studies (FDA 21CFR Part 58)
✓

OECD Principles on Good Laboratory Practice (as revised in 1997)
✓

Good Management Practices for Clinical Trials of Medical Devices (National Medical Products Administration (NMPA), May 2022)
✓

The implementation of this test follows the changes in test methods and test protocols and the agency’s Standard Operating Procedure (SOP)
✓

SGene follows a strict code of ethics for animal handling and welfare. Each research experiment and procedure is approved by the ethics committee and complies with animal protection laws, ethical laws, and animal welfare regulations.

SGene has obtained CNAS laboratory animal institution certification and is qualified to use all species of experimental animals. It always regards replacement, reduction and improvement (3Rs) as a key consideration. Years of experience in animal research and breeding enable us to provide our clients with valuable advice (such as testing methods and their frequency, blood collection and anesthesia procedures) that will help reduce the suffering of laboratory animals and reduce physiological side effects that may affect the results of animal research.

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About

About SGene

Our Vision, Mission & Values

Vision

Mission

Values

Cloning Platform

Editing Platform

Our History —— Corporate Development

Sinogene company established

R&D team built up for dog cloning

Sinogene Biotechnology Lab established in US

Sinogene CRO Beijing established

Sinogene Jiangsu established

Sinogene CRO Shanghai established

Our History —— Technology Development

2016.12

World's first gene-edited atherosclerosis canine model "Apple"

2017.05

China's first somatic cell cloned dog "Longlong" is born

2018.02

World's first gene-edited autism canine model

2018.04

China’s first batch of “test tube dogs” are born

2018.05

China’s first commercially cloned dog born

2018.06

World's first IVM-IVF dog is born

2018.12

China's first cloned police dog "Kunxun" is born

2019.06

World's first point-mutated diabetes canine model

2019.07

Chinese cloned cat "Garlic" is born

2019.08

Capital Public Security Bureau’s first batch of cloned police dogs

2019.08

World's first gene-edited amaurosis canine model

2019.10

World's first gene-edited arrhythmia canine model

2020.07

World's first gene-edited Neurodevelopmental disorders canine model

2020.08

World's first longevity gene overexpression canine model

2020.12

World's first gene-edited canine model with developmental

2021.01

World's first gene-edited schizophrenia canine model

2021.05

World's first small blood vessel gene-edited canine model

2021.06

World's first DMD gene-edited canine model

2021.09

World's first gene-edited canine model for depression

2021.12

World's first gene-edited canine model with true micro-eyeballs

2022.02

World's first gene-edited oxytocin canine model

2022.06

World's first cloned Arctic Wolf is born

2022.06

China's first registered cloned warm blooded horse

2022.09

World‘s first klotho gene-edited pig model

2022.10

Gene-edited mucopolysaccharidosis rabbit model

Core Team

Jidong Mi

Chairman and General Manager

Jianping Zhao

​Director/Executive Deputy General Manager

Liangxue Lai

Chief Scientist

Yuan Li

​Director of Animal Model R&D Department

Haiyang Hao

​Animal Model researcher

Xu Wei

Director/Executive Deputy General Manager

Director of Animal Model R&D Department

Animal Model researcher