Supply List of Animal Models

Currently, more than 50 gene-edited large animal disease models involving dogs, pigs, cats and other species have been developed, or under research. Some examples are listed below:

SGene offers customized animal model development services, utilizing gene editing and cloning technologies. We specialize in creating gene-edited animal model, in dogs, cats, pigs, rabbits and mice, with specific gene phenotypes, including gene knockout, knock-in, and conditional expression. These customized models are highly valuable for translational research on human diseases such as mechanisms of action studies and drug efficacy evaluations, etc.

  • Cardiovascular Diseases

    1. Atherosclerosis canine model (ApoE)

    2. Arrhythmia canine model

    3. Small vessel disease canine model

    4. Hypertrophic cardiomyopathy cat model (under research)

    5. Cerebellar ataxia porcine model

    6. Atrial fibrillation porcine model

    7. Dilated cardiomyopathy porcine model

  • Malignant Tumors

    1. Gene-edited prostate cancer canine model

    2. Liposome delivery to liver cancer canine model (under research)

    3. Tumor porcine model

  • CNS Disorders

    1. Autism canine model (Shank3)

    2. Neurodevelopmental disorder canine model

    3. Schizophrenia canine model

    4. Alzheimer's disease canine model (under research)

    5. Amyotrophic lateral sclerosis porcine model

    6. PPARy knock-out porcine model

  • Metabolic Diseases

    1. Point mutation diabetic canine model (Gck)

    2. Gene-edited oxytocin canine model

    3. Mucopolysaccharidosis rabbit model (under research)

  • Rare Diseases

    1. Duchenne muscular dystrophy canine model

    2. ALS canine model (SOD1)

    3. Huntington's disease porcine model

    4. Duchenne muscular dystrophy porcine model

    5. Porcine model of adult progeria syndrome

    6. Porcine model of childhood progeria

  • Immunodeficiency Disorders

    1. Immunodeficient tool dog

    2. Immunodeficient mouse model (under research)

    3. Immunodeficient porcine model

  • Ophthalmology

    1. Black mongrel canine model

    2. Yellow spotted cat model (under research)

  • Others

    1. Permanent tooth development disorder canine model

    2. Longevity gene overexpression canine model

    3. Gene-edited progeria porcine model

    4. Albino porcine model

    5. hACE2 mouse model

    6. Pure-type alpha ectodermal dysplasia porcine model

    7. Humanized mouse model (under research)

    8. Inflammation porcine model

    9. Oct4-EGFP transgenic porcine model

    10. Xist knockout porcine model

    11. Four-color fluorescent porcine etc.