•Evaluation of safety and effectiveness of oral bone repair materials
•Extraction of the second and third mandibular premolars on both sides of the mandible
•Wound healing status (end point) •Histopathological examination (end point)
•Evaluation of safety and effectiveness of oral bone repair materials
•Extraction of the second and third mandibular premolars on both sides of the mandible
•Wound healing status (end point) •Histopathological examination (end point)
Dogs are widely used in dental bone meal animal experiments. Compared with other experimental animals, dogs are similar to humans in many aspects, including food habits, oral environment, bone composition, and bone density. Therefore, dogs were chosen as experimental animals in this experiment.
Tooth extraction process
Micro-CT, hard cutting machine, suture needle, suture thread, vernier caliper, ultrasonic osteotome, and conventional dental surgical instruments
New tissue after tooth extraction and filling
Micro-CT procedure after tooth extraction
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