Diverse Gene-editing Large Animal Models

Successfully developed and constructed gene editing large animal models spanning dogs, pigs, etc, covering a wide range of diseases.
Diverse Gene-editing Large Animal Models
Successfully developed and constructed gene edited large animal models spanning dogs, pigs, etc, covering a wide range of diseases.
Cutting-edge Technology Platform 
Advanced technology platform with exceptional expertise in animal cloning and gene-editing.
State-of-the-art Research Facilities 
Uper-sized research and development base including SPF animal breeding laboratories, large animal experimental platform, etc.
Exceptional Research and Development Team 
Highly skilled research and development team, with rich experience in preclinical CRO services, especially based on large animal models.
Global Leadership in Scientific Achievements 
Pioneering technological breakthroughs, including the world's first gene-edited canine model for atherosclerosis, autism, point mutation diabetes, glaucoma, andarrhythmia.

SGene offers customized animal model development services, utilizing gene editing and cloning technologies. We specialize in creating gene-edited animal model, in dogs, cats, pigs, rabbits and mice, etc.

We have also established over 50 gene-edited disease large animal models for purchase, contact us for more details.

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Pharmacology Research

SGene Preclinical CRO team offer pharmacology research and evaluation services for the following diseases, especially based on large animal models:

Evaluation of Safety and Effectiveness for Medical Devices

SGene Preclinical CRO team has rich experience in providing customized preclinical research services for medical device products.

Appropriate animals are selected to meet the regulatory requirements for safety and efficacy evaluations.

SGene CRO service platform is equipment with interventional rooms, microsurgery rooms and general surgery rooms and a complete central laboratories, ensuring we can set up various disease models and provide preclinical related services.

Interventional OperatIng Room

Large Animal Operating Room

Cell Room

Molecular Genetics Room

Pathology Laboratory

Clinical Laboratory

Protein Laboratory

Microbiology Laboratory

Ophthalmology Laboratory

Mass Spectrometry Room

lmaging Laboratory

China National Accreditation Service for Conformity Assessment (CNAS) 

SGene is fully committed to maintaining the highest standards of quality and compliance. We strictly adhere to Good Laboratory Practice (GLP) standards, ensuring that our Preclinical CRO service facilities meet the rigorous criteria set by the China National Accreditation Service for Conformity Assessment (CNAS) standards. Additionally, our workflow aligns with the stringent regulations established by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC).

Complete registration of P2 Laboratory, Microbiological laboratory and PCR laboratory 

License for the use of all strains of experimental animals 

Laboratory Animal Production License (Applicable to: dogs, pigs, cats, rabbits, rats, and mice)

​As of October 2023, 10 SCI articles have been published in major journals, with a cumulative impact factor of >110 points, and more than 25 invention patents have been authorized.
  • Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses

  • Species-dependent neuropathology in transgenic SOD1 pigs

  • Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer